Publications



  • Durcin M, Fleury A, Taillebois E, Hilairet G, Krupova Z, Henry C, Truchet S, Trötzmüller M, Köfeler H, Mabilleau G, Hue O, Andriantsitohaina R, Martin P, Le Lay S.
    Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles.
    J Extracell Vesicles. 2017 Apr 10;6(1):1305677. [OPEN ACCESS] Pubmed
  • Pessentheiner AR, Huber K, Pelzmann HJ, Prokesch A, Radner FPW, Wolinski H, Lindroos-Christensen J, Hoefler G, Rülicke T, Birner-Gruenberger R, Bilban M, Bogner-Strauss JG.
    APMAP interacts with lysyl oxidase-like proteins, and disruption of Apmap leads to beneficial visceral adipose tissue expansion.
    FASEB J. 2017 May 30. pii: fj.201601337R. [OPEN ACCESS] Pubmed
  • Lanfranchi E, Pavkov-Keller T, Koehler EM, Diepold M, Steiner K, Darnhofer B, Hartler J, Van Den Bergh T, Joosten HJ, Gruber-Khadjawi M, Thallinger GG, Birner-Gruenberger R, Gruber K, Winkler M,
    Glieder A.
    Enzyme discovery beyond homology: a unique hydroxynitrile lyase in the Bet v1 superfamily.
    Sci Rep. 2017 May 3;7:46738. [OPEN ACCESS] Pubmed
  • Planells-Palop V, Hazazi A, Feichtinger J, Jezkova J, Thallinger G, Alsiwiehri NO, Almutairi M, Parry L, Wakeman JA, McFarlane RJ.
    Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis.
    Mol Cancer. 2017 Apr 26;16(1):84. [OPEN ACCESS] Pubmed
  • Bhutada G, Kavšcek M, Ledesma-Amaro R, Thomas S, Rechberger GN, Nicaud JM, Natter K.
    Sugar versus fat: elimination of glycogen storage improves lipid accumulation in Yarrowia lipolytica.
    FEMS Yeast Res. 2017 Apr 17. [Epub ahead of print] [OPEN ACCESS] Pubmed
  • Triebl A, Trötzmüller M, Hartler J, Stojakovic T, Köfeler HC.
    Lipidomics by ultrahigh performance liquid chromatography-high resolution mass spectrometry and its application to complex biological samples.
    J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 15;1053:72-80. [OPEN ACCESS] Pubmed
  • Eicher B, Heberle FA, Marquardt D, Rechberger GN, Katsaras J,
    Pabst G.
    Joint small-angle X-ray and neutron scattering data analysis of asymmetric lipid vesicles
    J Appl Crystallogr. 2017 Feb 28;50(Pt 2):419-429. [OPEN ACCESS] Pubmed
  • Deutsch AJA, Rinner B, Pichler M, Prochazka K, Pansy K, Bischof M, Fechter K, Hatzl S, Feichtinger J, Wenzl K, Frisch MT, Stiegelbauer V, Prokesch A, Krogsdam A, Sill H, Thallinger GG, Greinix HT, Wang C, Beham-Schmid C, Neumeister P.
    NR4A3 Suppresses Lymphomagenesis through Induction of Proapoptotic Genes.
    Cancer Res. 2017 May 1;77(9):2375-2386. [OPEN ACCESS] Pubmed
  • Kohler V, Probst I, Aufschnaiter A, Büttner S, Schaden L, Rechberger GN, Koraimann G, Grohmann E, Keller W.
    Conjugative type IV secretion in Gram-positive pathogens: TraG, a lytic transglycosylase and endopeptidase, interacts withtranslocation channel protein TraM.
    Plasmid. 2017 Feb 17;91:9-18. [OPEN ACCESS] Pubmed
  • Triebl A, Hartler J, Trötzmüller M, Köfeler HC.
    Lipidomics: Prospects from a technological perspective.
    Biochim Biophys Acta. 2017 Mar 22 pii: S1388-1981(17)30052-5. [OPEN ACCESS] Pubmed
  • Riessberger-Gallé U, Hernández-López J, Rechberger G, Crailsheim K, Schuehly W.
    Lysophosphatidylcholine acts in the constitutive immune defence against American foulbrood in adult honeybees.
    Sci Rep. 2016 Aug 2;6:30699. [OPEN ACCESS] Pubmed
  • Karbiener M, Darnhofer B, Frisch MT, Rinner B, Birner-Gruenberger R,Gugatschka M.
    Comparative proteomics of paired vocal fold and oral mucosa fibroblasts.
    J Proteomics. 2017 Jan 15;155:11-21. [OPEN ACCESS] Pubmed
  • Hofer DC, Pessentheiner AR, Pelzmann HJ, Schlager S, Madreiter-Sokolowski CT, Kolb D, Eichmann TO, Rechberger G, Bilban M, Graier WF, Kratky D, Bogner-Strauss JG.
    Critical role of the peroxisomal protein PEX16 in white adipocyte development and lipid homeostasis.
    Biochim Biophys Acta. 2017 Mar;1862(3):358-368. [OPEN ACCESS] Pubmed
  • Wallace PW, Haernvall K, Ribitsch D, Zitzenbacher S, Schittmayer M, Steinkellner G, Gruber K, Guebitz GM, Birner-Gruenberger R.
    PpEst is a novel PBAT degrading polyesterase identified by proteomic screening of Pseudomonas pseudoalcaligenes.
    Appl Microbiol Biotechnol. 2016 Nov 21. [OPEN ACCESS] Pubmed
  • Mitterer V, Gantenbein N, Birner-Gruenberger R, Murat G, Bergler H, Kressler D, Pertschy B.
    Nuclear import of dimerized ribosomal protein Rps3 in complex with its chaperone Yar1.
    Sci Rep. 2016 Nov 7. [OPEN ACCESS] Pubmed
  • Meng C, Zeleznik OA, Thallinger GG, Kuster B, Gholami AM,
    Culhane AC.
    Dimension reduction techniques for the integrative analysis of
    multi-omics data.

    Brief Bioinform. 2016;17(4):628-41. [OPEN ACCESS] Pubmed
  • Smith RC, King JG, Tao D, Zeleznik OA, Brando C, Thallinger GG, Dinglasan RR.
    Molecular profiling of phagocytic immune cells in Anopheles gambiae reveals integral roles for hemocytes in mosquito innate immunity.
    Mol Cell Proteomics. 2016 Sep 13. Pubmed
  • Krainer FW, Gerstmann MA, Darnhofer B, Birner-Gruenberger R,
    Glieder A.
    Biotechnological advances towards an enhanced peroxidase production in Pichia pastoris.
    J Biotechnol. 2016 Sep 10;233:181-9.​ [OPEN ACCESS] Pubmed
  • Klapper M, Findeis D, Koefeler H, Döring F.
    Methyl group donors abrogate adaptive responses to dietary restriction in C. elegans.
    Genes Nutr. 2016 Mar 17​. [OPEN ACCESS] Pubmed
  • Ulz P, Thallinger GG, Auer M, Graf R, Kashofer K, Jahn SW, Abete L, Pristauz G, Petru E, Geigl JB, Heitzer E, Speicher MR.
    Inferring expressed genes by whole-genome sequencing of plasma DNA.
    Nat Genet. 2016 Aug 29. [OPEN ACCESS] Pubmed
  • Krause R, Halwachs B, Thallinger GG, Klymiuk I, Gorkiewicz G, Hoenigl M, Prattes J, Valentin T, Heidrich K, Buzina W, Salzer HJ, Rabensteiner J, Prüller F, Raggam RB, Meinitzer A, Moissl-Eichinger C, Högenauer C, Quehenberger F, Kashofer K, Zollner-Schwetz I.
    Characterisation of Candida within the Mycobiome/Microbiome of the Lower Respiratory Tract of ICU Patients.
    PLoS One. 2016 May 20. [OPEN ACCESS] Pubmed
  • Birner-Gruenberger R, Breinbauer R.
    Tracking Protein S-Fatty Acylation with Proteomics.
    Chembiochem. 2016 Jun 6. [OPEN ACCESS] Pubmed
  • Weinhandl K, Ballach M, Winkler M, Ahmad M, Glieder A, Birner-Gruenberger R, Fotheringham I, Escalettes F, Camattari A.
    Pichia pastoris mutants as host strains for efficient secretion of recombinant branched chain aminotransferase (BCAT).
    J Biotechnol. 2016 Jun 7. [OPEN ACCESS] Pubmed
  • Gomez-Escobar N, Almobadel N, Alzahrani O, Feichtinger J, Planells-Palop V, Alshehri Z, Thallinger GG, Wakeman JA, McFarlane RJ.
    Translin and Trax differentially regulate telomere-associated transcript homeostasis.
    Oncotarget. 2016 May 10 [OPEN ACCESS] Pubmed
  • Radović B, Vujić N, Leopold C, Schlager S, Goeritzer M, Patankar JV, Korbelius M, Kolb D, Reindl J, Wegscheider M, Tomin T, Birner-Gruenberger R, Schittmayer M, Groschner L, Magnes C, Diwoky C, Frank S, Steyrer E, Du H, Graier WF, Madl T, Kratky D.
    Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice.
    Diabetologia. 2016 May 6. [OPEN ACCESS] Pubmed
  • Sturmberger L, Chappell T, Geier M, Krainer F, Day KJ, Vide U, Trstenjak S, Schiefer A, Richardson T, Soriaga L, Darnhofer B, Birner-Gruenberger R, Glick BS, Tolstorukov I, Cregg J, Madden K, Glieder A.
    Refined Pichia pastoris reference genome sequence.
    J Biotechnol. 2016 Apr 12. pii: S0168-1656(16)30203-6.
    [OPEN ACCESS] Pubmed
  • Pavkov-Keller T, Bakhuis J, Steinkellner G, Jolink F, Keijmel E, Birner-Gruenberger R, Gruber K.
    Structures of almond Hydroxynitrile Lyase Isoenzyme 5 provide a rationale for the lack of oxidoreductase activity in flavin dependent HNLS.
    J Biotechnol. 2016 Apr 8. pii: S0168-1656(16)30193-6.
    [OPEN ACCESS] Pubmed
  • Prokesch A, Pelzmann HJ, Pessentheiner AR, Huber K, Madreiter-Sokolowski CT, Drougard A, Schittmayer M, Kolb D, Magnes C, Trausinger G, Graier WF, Birner-Gruenberger R, Pospisilik JA, Bogner-Strauss JG.
    N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes.
    Sci Rep. 2016 Apr 5;6:23723. [OPEN ACCESS] Pubmed
  • Suárez-Calvet M, Neumann M, Arzberger T, Abou-Ajram C, Funk E, Hartmann H, Edbauer D, Kremmer E, Göbl C, Resch M, Bourgeois B, Madl T, Reber S, Jutzi D, Ruepp MD, Mackenzie IR, Ansorge O, Dormann D, Haass C.
    Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.
    Acta Neuropathol. 2016 Apr;131(4):587-604. [OPEN ACCESS] Pubmed
  • Schittmayer M, Fritz K, Liesinger L, Griss J, Birner-Gruenberger R.
    Cleaning out the Litterbox of Proteomic Scientists' Favorite Pet: Optimized Data Analysis Avoiding Trypsin Artifacts.
    J Proteome Res. 2016 Apr 1;15(4):1222-9. [OPEN ACCESS] Pubmed
  • Anvarian Z, Nojima H, van Kappel EC, Madl T, Spit M, Viertler M, Jordens I, Low TY, van Scherpenzeel RC, Kuper I, Richter K, Heck AJ, Boelens R, Vincent JP, Rüdiger SG, Maurice MM.
    Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.
    Nat Struct Mol Biol. 2016 Apr;23(4):324-32. [OPEN ACCESS] Pubmed
  • Kollau A, Russwurm M, Neubauer A, Rechberger G, Schmidt K, Koesling D, Fassett J, Schrammel A, Mayer B.
    Scavenging of nitric oxide by hemoglobin in the tunica media of porcine coronary arteries.
    Nitric Oxide. 2016 Apr 1;54:8-14. [OPEN ACCESS] Pubmed
  • Schmökel V, Memar N, Wiekenberg A, Trotzmüller M, Schnabel R,
    Döring F.
    Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos.
    Genetics. 2016 Mar;202(3):1071-83. [OPEN ACCESS] Pubmed
  • Vogl T, Sturmberger L, Kickenweiz T, Wasmayer R, Schmid C, Hatzl AM, Gerstmann MA, Pitzer J, Wagner M, Thallinger GG, Geier M, Glieder A.
    A Toolbox of Diverse Promoters Related to Methanol Utilization: Functionally Verified Parts for Heterologous Pathway Expression in Pichia pastoris.
    ACS Synth Biol. 2016 Feb 19;5(2):172-86. [OPEN ACCESS] Pubmed
  • Krainer FW, Darnhofer B, Birner-Gruenberger R, Glieder A.
    Recombinant production of a peroxidase-protein G fusion protein in Pichia pastoris.
    J Biotechnol. 2016 Feb 10;219:24-7. [OPEN ACCESS] Pubmed
  • Tomazic PV, Birner-Gruenberger R, Leitner A, Spoerk S, Lang-Loidolt D.
    Seasonal proteome changes of nasal mucus reflect perennial inflammatory response and reduced defence mechanisms and plasticity in allergic rhinitis.
    J Proteomics. 2016 Feb 5;133:153-60. [OPEN ACCESS] Pubmed
  • Weber J, Bao H, Hartlmüller C, Wang Z, Windhager A, Janowski R, Madl T, Jin P, Niessing D.
    Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.
    Elife. 2016 Jan 8;5. pii: e11297. doi: 10.7554/eLife.11297.
    [OPEN ACCESS] Pubmed
  • Nusshold C, Üllen A, Kogelnik N, Bernhart E, Reicher H, Plastira I, Glasnov T, Zangger K, Rechberger G, Kollroser M, Fauler G, Wolinski H, Weksler BB, Romero IA, Kohlwein SD, Couraud PO, Malle E, Sattler W.
    Assessment of electrophile damage in a human brain endothelial cell line utilizing a clickable alkyne analog of 2-chlorohexadecanal.
    Free Radic Biol Med. 2016 Jan;90:59-74. [OPEN ACCESS] Pubmed
  • Sturmberger L, Wallace PW, Glieder A, Birner-Gruenberger R.
    Synergism of proteomics and mRNA sequencing for enzyme discovery.
    J Biotechnol. 2015 Dec 18. pii: S0168-1656(15)30215-7.
    [OPEN ACCESS] Pubmed
  • Haslbeck V, Eckl JM, Drazic A, Rutz DA, Lorenz OR, Zimmermann K, Kriehuber T, Lindemann C, Madl T, Richter K.
    The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90.
    SciRep. 2015 Nov 23;5:17058. [OPEN ACCESS] Pubmed
  • Leypold M, Wallace PW, Kljajic M, Schittmayer M, Pletz J, Illaszewicz-Trattner C, Guebitz GM, Birner-Gruenberger R, Breinbauer R.
    A robust and simple protocol for the synthesis of arylfluorophosphonates.
    Tetrahedron Letters 2015 Oct;56(41):5619-5622. ScienceDirect
  • Fuchs, R; Stracke, A; Ebner, N; Zeller, CW; Raninger, AM; Schittmayer, M; Kueznik, T; Absenger-Novak, M; Birner-Gruenberger, R.
    The cytotoxicity of the α1-adrenoceptor antagonist prazosin is linked to an endocytotic mechanism equivalent to transport-P.
    Toxicology. 2015; 338:17-29 [OPEN ACCESS] Pubmed
  • Birner-Gruenberger, R; Breinbauer, R.
    Weighing the proteasome for covalent modifications.
    Chem Biol. 2015; 22(3):315-6 Pubmed

  • Aradska, J; Bulat, T; Sialana, FJ; Birner-Gruenberger, R; Erich, B;
    Lubec, G.
    Gel-free mass spectrometry analysis of Drosophila melanogaster heads.
    Proteomics. 2015; 15(19):3356-60 Pubmed

  • Hacker, C; Christ, NA; Duchardt-Ferner, E; Korn S, Göbl, C; Berninger, L; Düsterhus, S; Hellmich, UA; Madl, T; Kötter, P; Entian, KD; Wöhnert, J.
    The solution structure of the lantibiotic immunity protein NisI and its interactions with nisin.
    J Biol Chem. 2015; in press [OPEN ACCESS] Pubmed

  • Kavšček, M; Bhutada, G; Madl, T; Natter, K.
    Optimization of lipid production with a genome-scale model of Yarrowia lipolytica.
    BMC Syst Biol. 2015; 9:72 [OPEN ACCESS] Pubmed

  • Sala, P; Pötz, S; Brunner, M; Trötzmüller, M; Fauland, A; Triebl, A; Hartler, J; Lankmayr, E; Köfeler, HC.
    Determination of oxidized phosphatidylcholines by hydrophilic interaction liquid chromatography coupled to Fourier transform mass spectrometry.
    Int J Mol Sci. 2015; 16(4):8351-63 [OPEN ACCESS] Pubmed

  • Eichmann, TO; Grumet, L; Taschler, U; Hartler, J; Heier, C; Woblistin, A; Pajed, L; Kollroser, M; Rechberger, G; Thallinger, GG; Zechner, R; Haemmerle, G; Zimmermann, R; Lass, A.
    ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6.
    J Lipid Res. 2015; 56(10):1972-84 [OPEN ACCESS] Pubmed

  • Wolinski, H; Hofbauer, HF; Hellauer, K; Cristobal-Sarramian, A; Kolb, D; Radulovic, M; Knittelfelder, OL; Rechberger, GN; Kohlwein, SD.
    Seipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeast.
    Biochim Biophys Acta. 2015; 1851(11):1450-64 [OPEN ACCESS] Pubmed

  • Troppan, K; Wenzl, K; Pichler, M; Pursche, B; Schwarzenbacher, D; Feichtinger, J; Thallinger, GG; Beham-Schmid, C; Neumeister, P; Deutsch, A.
    miR-199a and miR-497 Are Associated with Better Overall Survival due to Increased Chemosensitivity in Diffuse Large B-Cell Lymphoma Patients.
    Int J Mol Sci. 2015; 16(8):18077-95 [OPEN ACCESS] Pubmed

  • Tomescu, OA; Mattanovich, D; Thallinger, GG.
    Integrative omics analysis. A study based on Plasmodium falciparum mRNA and protein data.
    BMC Syst Biol. 2014; 8 Suppl2:S4 [OPEN ACCESS] Pubmed

  • Schellenberg, JJ; Verbeke, TJ; McQueen, P; Krokhin, OV; Zhang, X; Alvare, G; Fristensky, B; Thallinger, GG; Henrissat, B; Wilkins, JA; Levin, DB; Sparling, R.
    Enhanced whole genome sequence and annotation of Clostridium stercorarium DSM8532T using RNA-seq transcriptomics and high-throughput proteomics.
    BMC Genomics. 2014; 15:567 [OPEN ACCESS] Pubmed

  • Vogl, T; Thallinger, GG; Zellnig, G; Drew, D; Cregg, JM; Glieder, A; Freigassner, M.
    Towards improved membrane protein production in Pichia pastoris: general and specific transcriptional response to membrane protein overexpression.
    N Biotechnol. 2014; 31(6):538-52 Pubmed

  • Sahu-Osen, A; Montero-Moran, G; Schittmayer, M; Fritz, K; Dinh, A; Chang, YF; McMahon, D; Boeszoermenyi, A; Cornaciu, I; Russell, D; Oberer, M; Carman, GM; Birner-Gruenberger, R; Brasaemle, DL.
    CGI-58/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization.
    J Lipid Res. 2015; 56(1):109-121 [OPEN ACCESS] Pubmed

  • Wildberger, P; Pfeiffer, M; Brecker, L; Rechberger, GN; Birner-Gruenberger, R; Nidetzky, B.
    Phosphoryl Transfer from α-d-Glucose 1-Phosphate Catalyzed by Escherichia coli Sugar-Phosphate Phosphatases of Two Protein Superfamily Types.
    Appl Environ Microbiol. 2015; 81(5):1559-1572 Pubmed

  • Knittelfelder OL; Weberhofer BP; Eichmann TO; Kohlwein SD; Rechberger GN.
    A versatile ultra-high performance LC-MS method for lipid profiling.
    J Chromatogr B Analyt Technol Biomed Life Sci. 2014; 951-952:119-28 [OPEN ACCESS] Pubmed

  • Tomazic, PV; Birner-Gruenberger, R; Leitner, A; Darnhofer, B; Spoerk, S; Lang-Loidolt, D.
    Apolipoproteins have a potential role in nasal mucus of allergic rhinitis patients: A proteomic study.
    Laryngoscope. 2015; 125(3):E91-6 Pubmed

  • Hartler, J; Koefeler, H; Troetzmueller, M; Thallinger, GG; Spener, F.
    Assessment of lipidomic species in hepatocyte lipid droplets from stressed mouse models.
    Sci Data 2014; 1:140051 [OPEN ACCESS] Pubmed

  • Triebl, A; Troetzmueller, M; Eberl, A; Hanel, P; Hartler, J; Koefeler, HC.
    Quantitation of phosphatidic acid and lysophosphatidic acid molecular species using hydrophilic interaction liquid chromatography coupled to electrospray ionization high resolution mass spectrometry.
    J Chromatogr A. 2014; 1347:104-110 Pubmed

  • Birner-Gruenberger, R; Schittmayer, M; Holzer, M; Marsche, G.
    Understanding high-density lipoprotein function in disease: Recent advances in proteomics unravel the complexity of its composition and biology.
    Prog Lipid Res. 2014; 56C:36-46 [OPEN ACCESS] Pubmed

  • Cavalcante Hissa, D; Arruda Bezerra, G; Birner-Gruenberger, R; Paulino Silva, L; Usón, I; Gruber, K; Maciel Melo, VM.
    Unique Crystal Structure of a Novel Surfactant Protein from the Foam Nest of the Frog Leptodactylus vastus.
    Chembiochem. 2014; 15(3):393-398 Pubmed

  • Tomazic, PV; Birner-Gruenberger, R; Leitner, A; Obrist, B; Spoerk, S; Lang-Loidolt, D.
    Nasal mucus proteomic changes reflect altered immune responses and epithelial permeability in patients with allergic rhinitis.
    J Allergy Clin Immunol. 2014; 133(3):741-750 Pubmed

  • Heo, S; Spoerk, S; Birner-Gruenberger, R; Lubec, G.
    Gel-based mass spectrometric analysis of hippocampal transmembrane proteins using high resolution LTQ Orbitrap Velos Pro.
    Proteomics. 2014; 14(17-18):2084-2088 Pubmed

  • Sreckovic, I; Birner-Gruenberger, R; Besenboeck, C; Miljkovic, M; Stojakovic, T; Scharnagl, H; Marsche, G; Lang, U; Kotur-Stevuljevic, J; Jelic-Ivanovic, Z; Desoye, G; Wadsack, C.
    Gestational diabetes mellitus modulates neonatal high-density lipoprotein composition and its functional heterogeneity.
    Biochim Biophys Acta. 2014; 1841(11):1619-1627 Pubmed

  • Kopecky, C; Haidinger, M; Birner-Gruenberger, R; Darnhofer, B; Kaltenecker, CC; Marsche, G; Holzer, M; Weichhart, T; Antlanger, M; Kovarik, JJ; Werzowa, J; Hecking, M; Säemann, MD.
    Restoration of Renal Function Does Not Correct Impairment of Uremic HDL Properties.
    J Am Soc Nephrol. 2014; 26(3):565-75. Pubmed